Concepedia

Calicheamicin-conjugated humanized anti-CD33 monoclonal antibody (gemtuzumab zogamicin, CMA-676) shows cytocidal effect on CD33-positive leukemia cell lines, but is inactive on P-glycoprotein-expressing sublines

Kensuke Naito, Akihiro Takeshita, Kohichiro Shigeno, Shota Nakamura, Shinya Fujisawa, Kaori Shinjo, Hiromu Yoshida, Kazunori Ohnishi, M. MORI, S. Terakawa,

Leukemia · 2000 · 152 citations · 33 references

DOI

Concepts

References

33

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

Zhixiang Shen, Guoqiang Chen, Jian-Hua Ni et al. · Blood · 1997 · 1.4K citations

, , +17

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

Karen S. Sellins, John Cohen · The Journal of Immunology · 1987 · 925 citations

, , +16

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

Norbert Kartner, Deanna Evernden-Porelle, Grace Bradley et al. · Nature · 1985 · 922 citations

, , +11

Calichemicins, a novel family of antitumor antibiotics. 2. Chemistry and structure of calichemicin .gamma.1I

May D. Lee, T. S. DUNNE, Conway C. Chang et al. · Journal of the American Chemical Society · 1987 · 520 citations

, , +6

Selective Ablation of Acute Myeloid Leukemia Using Antibody-Targeted Chemotherapy: A Phase I Study of an Anti-CD33 Calicheamicin Immunoconjugate

Eric L. Sievers, F R Appelbaum, Ricardo Spielberger et al. · Blood · 1999 · 456 citations

, , +14