Adaptive Behavior of Dynamic Combinatorial Libraries Generated by Assembly of Different Building Blocks

Abstract

Democratic behavior: A strong bias for the amplification of assemblies, the composition of which reflects the overall composition of the library, can be observed in selection processes with dynamic combinatorial libraries. As a consequence, it is not necessarily the assembly with the highest affinity to a given target (for example, a substrate, see scheme) that is amplified the most. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z51623_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.