Cathelicidin-Deficient (<i>Cnlp</i>⁻^/⁻) Mice Show Increased Susceptibility to<i>Pseudomonas aeruginosa</i>Keratitis

Abstract

Cathelicidin-deficient mice showed considerable susceptibility to PA keratitis. The present study demonstrates direct in vivo evidence that endogenous expression of cathelicidin provides defense against corneal PA infection indicating its importance in host innate immunity at the ocular surface.