Applied Physics Letters · 2008 · 291 citations · 13 references
Cold Atmospheric PlasmaEngineeringPlasma JetPlasma TheoryPlasma SimulationPlasma TransportHelium FlowPlasma PhysicsWound HealingBiomedical EngineeringPlasma ConfinementGas Discharge PlasmaNonthermal PlasmaMedicineCell BiologyPlasma ApplicationCell Detachment
The study examined how a cold atmospheric plasma jet interacts with fibroblast cells. The plasma jet was generated by applying high‑frequency AC voltage to electrodes in a helium flow, producing a 5 cm long, 1.5–2 mm diameter jet. Plasma treatment reduced fibroblast migration, induced cell detachment, and produced frozen cells, whereas helium flow alone only caused frozen cells, indicating that response intensity depends on plasma exposure.
The interaction of the cold atmospheric plasma jet with fibroblast cells was studied. Plasma jet was initiated in the helium flow blowing through the syringe by application of high ac voltage to the discharge electrodes. The plasma jet had a length of 5cm and a diameter of 1.5–2mm in ambient air. Treatment of cells with plasma jet resulted in decreasing of cell migration rate, cell detachment, and appearance of “frozen” cells, while treatment with helium flow (no plasma) resulted in appearance of frozen cells only. A variety of cellular responses was explained by different intensities of treatment.
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K. Becker, Karl H. Schoenbach, J. G. Eden · Journal of Physics D Applied Physics · 2006 · 895 citations