Expression of P-glycoprotein in inner ear capillary endothelial cells of the guinea pig with special reference to blood–inner ear barrier

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

Expression of Multidrug Resistance Gene in Human Cancers

Lori J. Goldstein, Hanan Galski, Antonio Tito Fojo et al. · JNCI Journal of the National Cancer Institute · 1989 · 1.3K citations

Medicine, Cancer Biology, Oncology +11

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Journal of Histochemistry & Cytochemistry · 1989 · 610 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Functional involvement of P-glycoprotein in blood-brain barrier.

T Tatsuta, Mikihiko Naito, Tomoko Oh‐hara et al. · Journal of Biological Chemistry · 1992 · 353 citations · Full text

Medicine, Cell Biology, Pharmacology +17