Neutrophils Establish Rapid and Robust WAVE Complex Polarity in an Actin-Dependent Fashion

Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

Laura M. Machesky, Robert H. Insall · Current Biology · 1998 · 929 citations · Full text

Protein Function, Signal Transduction, Natural Sciences +11

Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

Guy Servant, Orion D. Weiner, Paul Herzmark et al. · Science · 2000 · 880 citations

Innate Immune System, Immunology, Green Fluorescent Protein +20

Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils

Jingsong Xu, Fei Wang, Alexandra Van Keymeulen et al. · Cell · 2003 · 692 citations · Full text

Biophysical Modeling, Pattern Formation, Signal Transduction +9

G Protein Signaling Events Are Activated at the Leading Edge of Chemotactic Cells

Carole A. Parent, Brenda J. Blacklock, Wendy Froehlich et al. · Cell · 1998 · 621 citations · Full text

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

Ruedi Meili · The EMBO Journal · 1999 · 441 citations · Full text

Efficient Chemotaxis, Signal Transduction, Molecular Physiology +14