Concepedia

<scp>OCTET</scp>‐<scp>CY</scp>: a phase <scp>II</scp> study to investigate the efficacy of post‐transplant cyclophosphamide as sole graft‐versus‐host prophylaxis after allogeneic peripheral blood stem cell transplantation

Udo Holtick, Jens‐Markus Chemnitz, Alexander Shimabukuro‐Vornhagen, Sebastian Theurich, Geothy Chakupurakal, Anke Krause, Anne Fiedler, Leo Luznik, Martin Hellmich, Dominik Wolf‎,

European Journal Of Haematology · 2015 · 64 citations · 31 references

DOIFull text

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Abstract

Post-transplant cyclophosphamide as sole IS in PBSCT is feasible and allows rapid immune recovery. Increased rates of severe acute GvHD explain the observed NRM and may advise a temporary combination partner such as mTor-inhibitors in the PBSCT setting.

References

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