Antimicrobial Agents and Chemotherapy · 2013 · 17 citations · 10 references
MedicineNephrologyPharmacologyKidney TransplantationRenal PharmacokineticsRenal PharmacotherapyRenal AssessmentRenal ClearanceRenal Dose AdjustmentRenal Drug ClearanceRenal Function TestingRenal Function Tests24-Hour Urine Creatinine ClearanceEstimated Creatinine ClearanceGlomerular Filtration AssessmentGlomerular Filtration Rate AssessmentGlomerular Filtration Rate MeasurementKidney Function MonitoringRenal Dosing AppropriatenessRenal Dysfunction Assessment
In a prospective study of solid-organ transplant recipients (n = 22; 15 hepatic and 7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24-h urine creatinine clearance) by >20% in 14/22 (63.6%). Its use was associated with inappropriate underdosing of valganciclovir, while the Cockroft-Gault equation was accurate in 21/22 patients (95.4%). Subtherapeutic ganciclovir levels (≤ 0.6 mg/liter) were common, occurring in 10/22 patients (45.4%); 7 had severely deficient levels (<0.3 mg/liter).
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A New Equation to Estimate Glomerular Filtration Rate
Andrew S. Levey, Lesley A. Stevens, Christopher H. Schmid et al. · Annals of Internal Medicine · 2009 · 25.7K citations
Pharmacy, Nephrology, Physiology +12