Comparative Trial of the Safety and Immunogenicity of Quadrivalent (A, C, Y, W-135) Meningococcal Polysaccharide-Diphtheria Conjugate Vaccine Versus Quadrivalent Polysaccharide Vaccine in Two- to Ten-Year-Old Children

Michael E. Pichichero, Janet R. Casey, Mark M. Blatter, Edward Rothstein, Robert Ryall, Mike Bybel, Gregory Gilmet, Thomas Papa

The Pediatric Infectious Disease Journal · 2005 · 120 citations · 10 references

Abstract

In 2- to 10-year-old children MCV-4 had a safety profile similar to that of PSV-4 and elicited significantly higher and more persistent serum bactericidal antibody responses against meningococcal serogroups A, C, Y and W-135 than did the licensed polysaccharide vaccine.

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