Inclusion Mode of 8-Anilino-1-naphthalenesulfonate (ANS) in the ANS-β-Cyclodextrin Complex

Abstract

Abstract The inclusion mode of 8-anilino-1-naphthalenesulfonate (ANS) in the ANS-β-cyclodextrin complex with a molar ratio of 1 : 1 in deuterium oxide was investigated by measurements of the proton nuclear magnetic resonance spectra and studies with Corey Pauling Koltun models. It was found that in the preferential inclusion mode of ANS, the whole benzene ring of ANS is enclosed at a considerable depth in the cavity of β-cyclodextrin from the side of the secondary hydroxyl group, and a great portion of the naphthalene ring is outside the cavity.