Concepedia

Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases

David A. Sandham, Nicola Arnold, Heinrich Aschauer, Kamlesh Bala, Lucy Barker, Lyndon Brown, Zarin Brown, David C. Budd, Brian J. Cox, Cerys Docx,

Bioorganic & Medicinal Chemistry · 2013 · 22 citations · 20 references

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20

Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma

Prevention Program · 1997 · 4.1K citations

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Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

Hiroyuki Hirai, Kazuya Tanaka, Osamu Yoshie et al. · The Journal of Experimental Medicine · 2001 · 1.1K citations · Full text

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Release of Prostaglandin D<sub>2</sub>into Human Airways during Acute Antigen Challenge

John Murray, André Bernard Tonnel, Alan Brash et al. · New England Journal of Medicine · 1986 · 475 citations

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Antagonism of the prostaglandin D <sub>2</sub> receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans

Kang Cheng, Tsuei-Ju Wu, Kenneth K. Wu et al. · Proceedings of the National Academy of Sciences · 2006 · 268 citations · Full text

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A randomized, double‐blind, placebo‐controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma

N. Barnes, Ian Pavord, John I. Bell et al. · Clinical & Experimental Allergy · 2011 · 217 citations · Full text

, , +14