Common C677T Polymorphism in the Methylenetetrahydrofolate Reductase Gene Increases the Risk for Deep Vein Thrombosis in Patients with Predisposition of Thrombophilia

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

Randall K. Saiki, David H. Gelfand, Susanne Stoffel et al. · Science · 1988 · 17.2K citations

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A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis

SR Poort, FR Rosendaal, PH Reitsma et al. · Blood · 1996 · 3.1K citations · Full text

Medicine, Genetics, Molecular Genetics +15

Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease

Robert Clarke, Leslie Daly, Killian Robinson et al. · New England Journal of Medicine · 1991 · 2.2K citations · Full text

Life Sciences, Biochemistry, Cardiology +15

Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.

Ian M. Graham · PubMed · 1997 · 1.8K citations

Medicine, Cardiology, Micronutrient Deficiency +14

A Prospective Study of Plasma Homocyst(e)ine and Risk of Myocardial Infarction in US Physicians

Meir J. Stampfer · JAMA · 1992 · 1.7K citations

Medicine, Cardiology, Internal Medicine +12