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Phosphinic peptide inhibitors as tools in the study of the function of zinc metallopeptidases
28
Citations
0
References
2000
Year
Combinatorial ChemistryBioorganic ChemistryMolecular BiologyChemical BiologyMedicinal ChemistryPhosphinic PeptidesProteomicsBiochemistryZinc MetallopeptidasesPhosphinic Peptide InhibitorsVarious Zinc MetalloproteinasesNon-peptide LigandPharmacologyNatural SciencesPeptide LibraryBioactive MetalMetalloproteinPeptide TherapeuticPeptide SynthesisProtein EngineeringMedicineDrug Discovery
The development of the combinatorial chemistry of phosphinic peptides has led to the discovery of both highly potent and selective inhibitors of various zinc metalloproteinases. Several properties of these compounds are reviewed, supporting the view that this class of inhibitors should represent useful tools for probing several aspects of the function of this broad family of proteases in vivo.