Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats

A SENSITIVE, PRECISE RADIOIMMUNOASSAY OF SERUM INSULIN RELYING ON CHARCOAL SEPARATION OF BOUND AND FREE HORMONE MOIETIES

J. D. M. Albano, R. P. Ekins, Gert S. Maritz et al. · European Journal of Endocrinology · 1972 · 624 citations

Medicine, Biochemistry, Endocrinology +13

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic ?-cells

Gerhard Trube, Patrik Rorsman, Takako Ohno‐Shosaku · Pflügers Archiv - European Journal of Physiology · 1986 · 573 citations

Natural Sciences, Pharmacology, Physiology +14

Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release.

Susan Bonner‐Weir, David Trent, Gordon C. Weir · Journal of Clinical Investigation · 1983 · 466 citations · Full text

Medicine, Endocrinology, Surgery +17

Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion.

J. A. Parsons, T. Clark Brelje, Robert L. Sorenson · Endocrinology · 1992 · 440 citations

Life Sciences, Endocrinology, Physiology +17

Increased β-Cell Secretory Capacity as Mechanism for Islet Adaptation to Nicotinic Acid-Induced Insulin Resistance

Steven E. Kahn, James C Beard, Michael W. Schwartz et al. · Diabetes · 1989 · 180 citations

Medicine, Endocrinology, Physiology +16