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Synthesis and structure–activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: Application of weakly basic sulfoximine group as novel S4 binding element

Structure–activity RelationshipMedicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug DesignMechanism Of ActionPharmacotherapyDrug DevelopmentChemical BiologyPharmacologyPharmaceutical ChemistryDrug Discovery