Concepedia

Synthesis and structure–activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: Application of weakly basic sulfoximine group as novel S4 binding element

Vrajesh B. Pandya, Mukul R. Jain, Ganes Chakrabarti, Hitesh Soni, Bhavesh Parmar, Balaji Chaugule, Jigar S. Patel, Tushar Jarag, Jignesh K. Joshi, Nirav Joshi,

European Journal of Medicinal Chemistry · 2012 · 42 citations · 21 references

DOIFull text

Open access

Concepts

References

21

Venous thromboembolism (VTE) in Europe

Giancarlo Agnelli, Frederick A. Anderson, Juan I. Arcelus et al. · Thrombosis and Haemostasis · 2007 · 1.6K citations

, , +15

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1<i>H</i>-pyrazolo[3,4-<i>c</i>]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Donald Pinto, Michael J. Orwat, Stephanie C. Koch et al. · Journal of Medicinal Chemistry · 2007 · 397 citations · Full text

, , +14

DU‐176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles

Taketoshi Furugohri, K. Isobe, Yuko Honda et al. · Journal of Thrombosis and Haemostasis · 2008 · 300 citations · Full text

, , +5

A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT)

Kenneth Bauer, Bruce L. Davidson, Michael Gent et al. · Thrombosis and Haemostasis · 2008 · 159 citations

, , +17

Chemistry of sulfoxides and related compounds. XXVI. Preparation and synthetic applications of (dimethylamino)phenyloxosulfonium methylide

Carl R. Johnson, Manfred Haake, Calvin W. Schroeck · Journal of the American Chemical Society · 1970 · 150 citations

, , +5