Double‐blind study of levamisole in aphthous stomatitis

Abstract

Abstract Sixty‐five patients with recurrent aphthous stomatitis participated in a double‐blind study to evaluate levamisole. Nineteen of 34 patients improved on levamisole and only five of 31 patients improved on placebo ( P >0.004, chi‐square with two degrees of freedom). After breaking the code and switching placebo patients to levamisole and non‐responders to an alternate dosage schedule, 46 of 60 patients noted clinical improvement. This is publication number 33 of the Dermatological Research Laboratories of Duke University Medical Center.