Nail Dyschromia Associated with Zidovudine

Abstract

Brief Reports15 January 1990Nail Dyschromia Associated with ZidovudinePhilip C. Don, MD, PhD, Francesca Fusco, MD, Philip Fried, MD, Amy Batterman, MD, Frederick P. Duncanson, MD, Theodore H. Lenox, MD, Natalie C. Klein, MDPhilip C. Don, MD, PhDSearch for more papers by this author, Francesca Fusco, MDSearch for more papers by this author, Philip Fried, MDSearch for more papers by this author, Amy Batterman, MDSearch for more papers by this author, Frederick P. Duncanson, MDSearch for more papers by this author, Theodore H. Lenox, MDSearch for more papers by this author, Natalie C. Klein, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-2-145 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCutaneous reactions to the drug zidovudine, used to treat patients ( 1 ) with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex, have been infrequently documented. In 1987, Furth and Kazakis (2) noted discoloration of the nail in two black patients on zidovudine. Subsequent case reports described seven patients with zidovudine and nail hyperpigmentation (3-7). Most were dark-skinned or of dark-skin ancestry and only one was a woman. We report the results of a study defining the incidence of zidovudine-associated nail dyschromia and other variables such as age, sex, race, risk factors, and immune status.Patients and MethodsWe did...References1. FischlRichmanGrieco MDM. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. N Engl J Med. 1987;317:185-91. CrossrefMedlineGoogle Scholar2. FurthKazakis PA. Nail pigmentation changes associated with azidothymidine (zidovudine). Ann Intern Med. 1987;107:350. LinkGoogle Scholar3. Panwalker A. Nail pigmentation in the acquired immunodeficiency syndrome (AIDS) [Letter]. Ann Intern Med. 1987;107:943-4. LinkGoogle Scholar4. VaiopoulosMangakisKarabinisKourtisFourtounisFessas GJAAPP. Pigmentation and azidothymidine [Letter]. Ann Intern Med. 1988;108:777. LinkGoogle Scholar5. Azon-MasoliverMallolasGatellCastel AJJT. Zidovudine-induced nail pigmentation [Letter]. Arch Dermatol. 1988;124:1570-1. CrossrefMedlineGoogle Scholar6. FisherMcPoland CP. Azidothymidine-induced nail pigmentation. Cutis. 1989;43:552-4. MedlineGoogle Scholar7. BendickRasokatSteigleder CHG. Azidothymidine-induced hyperpigmentation of skin and nails [Letter]. Arch Dermatol. 1989;125:1285-6. CrossrefMedlineGoogle Scholar8. LeydenSpottGoldschmidt JDH. Diffuse and banded melanin pigmentation in nails. Arch Dermatol. 1972;105:548-50. CrossrefMedlineGoogle Scholar9. Daniel C. Nail pigmentation abnormalities. In: Dermatologie Clinics; The Nail. Philadelphia: W.B. Saunders; 1985;3:431-3. CrossrefGoogle Scholar10. Dunagin W. Clinical toxicity of chemotherapeutic agents: dermatologic toxicity. Semin Oncol. 1982;9:14-22. MedlineGoogle Scholar11. BaranDawber RR. Diseases of the Nails and their Management. Oxford: Blackwell Scientific; 1984:249. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the New York Medical College and the Metropolitan Hospital Center, New York, New York. For current author addresses, see end of text. 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