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In vitro improvement of a shark IgNAR antibody by Qβ replicase mutation and ribosome display mimics in vivo affinity maturation

Natural SciencesDirected EvolutionShark Ignar AntibodyMolecular BiologyAntibody ScreeningProtein EngineeringAntibody EngineeringAnalytical UltracentrifugationSystems BiologyMedicineVivo Affinity MaturationProtein SynthesisQβ Replicase Mutation