Facilitation of Infection of Monkey Cells with Poliovirus "Ribonucleic Acid"

Abstract

The plaque titer of poliovirus "ribonucleic acid" on monkey kidney cells cultured in vitro is greatly increased by depleting these cells of calcium and treating the "ribonucleic acid" inoculum with a suspension of any one of several poorly water-soluble substances before inoculation. These undissolved substances apparently facilitate infection by serving as solid vehicles for the "ribonucleic acid."