Studies of the Blood Ammonia in Liver Disease

Abstract

Article1 January 1963Studies of the Blood Ammonia in Liver DiseaseIts Diagnostic, Prognostic, and Therapeutic SignificanceJULES STAHL, M.D., F.A.C.P. (HON.)JULES STAHL, M.D., F.A.C.P. (HON.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStudies on blood ammonia have a long experimental and biochemical record going back to the work of the Pavlov school on meat intoxication in dogs with Eck fistulas (1, 2). Later studies, using more satisfactory methods, were applied to the investigation of liver disease for the first time by Burchi in 1927 (3), by Van Caulaert and Deviller in their extensive studies in Strasbourg in 1932 (4), and by Esben Kirk in 1935 (5).Van Caulaert and Esben Kirk had noticed in cirrhotic subjects temporary elevation of the venous blood ammonia after an oral test dose of ammonium salts. 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