Regulation of BMAL1 Protein Stability and Circadian Function by GSK3β-Mediated Phosphorylation

Abstract

These findings uncover a previously unknown mechanism of circadian clock control. The GSK3beta kinase phosphorylates BMAL1, an event that controls the stability of the protein and the amplitude of circadian oscillation. BMAL1 phosphorylation appears to be an important regulatory step in maintaining the robustness of the circadian clock.