Tetrapeptide-amide analogues of enkephalin: The role of C-terminus in determining the character of opioid activity

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

W R Martin, C. G. Eades, JP Thompson et al. · Journal of Pharmacology and Experimental Therapeutics · 1976 · 3K citations

Medicine, Pharmacology, Veterinary Pharmacology +16

Endogenous opioid peptides: multiple agonists and receptors

John A.H. Lord, Angela A. Waterfield, John Hughes et al. · Nature · 1977 · 2.5K citations

Medicine, Pharmacology, Neuroendocrinology +9

C fragment of lipotropin has a high affinity for brain opiate receptors

A.F. Bradbury, D.G. Smyth, Christopher R. Snell et al. · Nature · 1976 · 486 citations

Life Sciences, Endocrinology, Neuroscience +5

The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog.

Paul E. Gilbert, William R. Martin · Journal of Pharmacology and Experimental Therapeutics · 1976 · 485 citations

Medicine, Pharmacology, Neuropharmacology +13