Blood · 2002 · 89 citations · 76 references
Life SciencesHematologyImmunologyImmunoregulationImmunotherapyTransplant ImmunologyAllograft RejectionGraft RejectionGraft-versus-host DiseaseInterferon ResponsesTransplant ImmunotherapyTransplant RejectionCd8 Positive T CellsCd8 T Cell ActivationDonor-recipient ImmunologyGraft Versus Host Disease ModulationGraft-versus-host Disease PathophysiologyImmunologic Response To AllograftT Cell - Mediated RejectionT-cell Mediated Rejection
The graft-versus-leukemia (GVL) effects and graft-versus-host disease (GVHD)-inducing activity of CD8 T cells was compared in murine recipients of wild-type (WT) or interferon gamma (IFN-gamma)-deficient (GKO) allogeneic donor cells. CD8 T cells (or CD4-depleted splenocytes) from GKO donor mice induced more severe GVHD in lethally irradiated allogeneic recipients compared to the same cell populations from WT donors. Consistent with GVHD severity, donor CD8 T-cell expansion in allogeneic recipients was augmented in the absence of IFN-gamma. These results demonstrate that IFN-gamma does not stimulate but instead down-modulates GVHD induced by donor CD8 T cells. Remarkably, antihost lymphohematopoietic reactions, including GVL effects against host leukemia/lymphoma cells, of CD8 T cells correlated inversely with their GVHD-inducing activity, and those of GKO donors were markedly weaker than those mediated by WT donor CD8 T cells. These data show for the first time that GVHD-inducing activity and GVL effects of allogeneic CD8 T cells can be separated by a single cytokine, IFN-gamma. (Blood. 2002;99:4207-4215)
76
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Stephen P. Schoenberger, René E. M. Toes, Ellen I. H. van der Voort et al. · Nature · 1998 · 2.6K citations
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Sally R.M. Bennett, Freda Karamalis, Richard A. Flavell et al. · Nature · 1998 · 2.1K citations