Analysis of drug transport and metabolism in cell monolayer systems that have been modified by cytochrome P4503A4 cDNA-expression

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

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Medicine, Gastroenterology, Pathology +10

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Per Artursson, Johan Karlsson · Biochemical and Biophysical Research Communications · 1991 · 1.8K citations

Health Sciences, Medicine, Physiology +9

Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture

M. Pinto · SPIRE - Sciences Po Institutional REpository · 1983 · 1.8K citations · Full text

Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells

John L. Yates, N Warren, Bill Sugden · Nature · 1985 · 1.3K citations

Viral Replication, Molecular Virology, Pathogenesis +9

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

Immunology, Cellular Pharmacology, Pharmacotherapy +16