Phenothiazine-Induced Phenytoin Intoxication

Abstract

Brief Reports1 July 1980Phenothiazine-Induced Phenytoin IntoxicationFREDERICK M. VINCENT, M.D.FREDERICK M. VINCENT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-1-56 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe simultaneous administration of two or more drugs may result in interactions that increase or decrease the intended effects of one or both drugs. It is well known that phenytoin metabolism may be affected by various medications; warfarin, disulfiram, chloramphenicol, diazepam, and isoniazid may all elevate blood levels of phenytoin and prolong its half-life (1-4). We have recently observed two patients with clinically significant phenytoin intoxication that occurred during concurrent administration of thioridazine.Patient 1, a 67-year-old woman, had been placed on phenytoin for 3 years (without side-effects) after the removal of a right parietal meningioma. Four years after discontinuing...References1. KUTTMCDOWELL HF. Management of epilepsy with diphenylhydantoin sodium: dosage regulation for problem patients. JAMA. 1968;203:969-72. CrossrefMedlineGoogle Scholar2. KUTTLOUIS HS. Anticonvulsant drugs: II. Clinical pharmacological and therapeutic aspects. Drugs. 1972;4:256-82. CrossrefMedlineGoogle Scholar3. LIVINGSTONBERMANPAULI SWL. Anticonvulsant drug blood levels: practical applications based on 12 years' experience. JAMA. 1975;232:60-2. CrossrefMedlineGoogle Scholar4. KUTT H. Interactions of antiepileptic drugs. Epilepsia. 1975;16:393-402. CrossrefMedlineGoogle Scholar5. REMMER H. The role of the liver in drug metabolism. Am J Med. 1970;49:617-29. CrossrefMedlineGoogle Scholar6. KUTTVEREBELY HK. Metabolism of diphenylhydantoin by rat liver microsomes: 1. Characteristics of the reaction. Biochem Pharamacol. 1970;19:673-86. CrossrefGoogle Scholar7. BOELHOUWERHENRYGLUECK CCB. Positive spiking: a double blind control study on its significance in behavior disorders, both diagnostically and therapeutically. Am J Psychiat. 1968;125:473-81. CrossrefMedlineGoogle Scholar8. ITILRIZZOSHAPIRO TAD. Study of behavior and EEG correlation during treatment of disturbed children. Dis Nerv Syst. 1967;28:731-6. MedlineGoogle Scholar9. SIRISPIPPENGERWERNERMASLAND JCWR. Anticonvulsant drug serum levels in psychiatric patients with seizure disorders: effects of certain psychotropic drugs. NY State J Med. 1974;74:1554-6. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FREDERICK M. VINCENT, M.D.Affiliations: Munson Medical Center Traverse City, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhenytoinPhenytoin-associated movement disorder: A literature reviewPhenytoinNeuroleptic drugsPhenytoinNEUROLEPTIC DRUGSPotential Drug Interactions and Duplicate Prescriptions Among Cancer PatientsInteraktionen zwischen Antiepileptika und PsychopharmakaNeuroleptic drugsAntiepileptic Drug-induced Movement DisordersAntiepileptic-Antipsychotic Drug Interactions: A Critical Review of the EvidenceClinical Significance of Pharmacokinetic Interactions Between Antiepileptic and Psychotropic DrugsInteractions Between Anticonvulsant and Psychoactive DrugsDrug Interactions with Agents Used in the Treatment of CNS DisordersPhenvtoin-induced focal choreaMetabolism of thioridazine by microsomal monooxygenases: relative roles of P450 and flavin-containing monooxygenasePhenytoin and dyskinesias: A report of two cases and review of the literatureFacioscapulohumeral syndrome with cardiomyopathyPhenytoin-induced choreoathetosis.Enzyme induction and inhibitionClinically Relevant Anti-Epileptic Drug InteractionsIn vitro inhibition of hepatic drug oxidation by thioridazinePsychopathology in Epilepsy: Prevalence, Phenomenology and ManagementEffect of Thioridazine on Phenytoin Serum Concentration: A Retrospective StudyPsychotropic drugs and epilepsyReferencesAntipsychotic Agents: A Clinical UpdateUpdate of cardiovascular drug interactionsAntiepileptic Drug InteractionsPhenytoin-induced orofacial dyskinesia. A case reportEpilepsy: Psychiatric aspects and use of psychotropicsInteractions Between Anticonvulsants and Other Commonly Prescribed DrugsDrug Treatment of SchizophreniaNeuroleptics and antipsychotic drugs 1 July 1980Volume 93, Issue 1_Part_1Page: 56-57KeywordsBloodChloramphenicolDiazepamDrug administrationDrug interactionsDrugsHalf lifeIntoxicationIsoniazidPatient advocacy ePublished: 1 December 2008 Issue Published: 1 July 1980 PDF downloadLoading ...