Concepedia

A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole

Zaida García‐Casado, Ángel Guerrero‐Zotano, Antonio Llombart‐Cussac, Ana Calatrava, Antonio Fernández‐Serra, Amparo Ruiz-Simón, Joaquín Gavilá, Miguel Ángel Climent, Sergio Almenar, José Cervera-Deval,

BMC Cancer · 2010 · 72 citations · 43 references

DOIFull text

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Abstract

Our study reveals that the rs4646 polymorphism identifies a subgroup of stage II-III ER/PgR [+] BC patients with poor response to neoadjuvant letrozole and poor prognosis. Testing for the rs4646 polymorphism could be a useful tool in order to orientate the treatment in elderly BC patients.

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