PEDIATRICS · 2006 · 66 citations · 12 references
PharmacySurgeryToxicologyEnvironmental ToxicologyHeavy Metal PoisoningHeavy Metal ToxicologyChelation TherapyLead ExposureLead PoisoningLead ToxicologyPediatric Heavy Metal PoisoningPediatric ToxicologyChildhood Environmental ExposureChildhood Environmental HealthChildhood Lead ExposureHeavy Metal Poisoning ManagementIngestion PoisoningLead IngestionOperative RemovalOral Chelation Therapy
In the past 3 decades, lead levels in North American children have been declining. Despite the decline in lead exposure, lead toxicity remains a significant childhood environmental health hazard. The usual route of lead exposure is through ingestion, but lead toxicity secondary to retained bullet fragments has been well documented in the adult literature. The diagnosis of lead toxicity is often difficult and delayed secondary to vague and transient symptoms. Recognizing high-risk characteristics of bullet fragments can improve clinician awareness to the possibility of lead toxicity. The primary management of patients with continued lead exposure is to remove the source of exposure. However, in the case of retained bullet fragments, initiation of chelation therapy before surgical removal may be essential in preventing systemic toxicity. We present the case of a 14-year-old female with lead toxicity who presented with an 18-month course of chronic abdominal pain, vomiting, and anorexia 2 years after sustaining a gunshot wound to the right leg. The patient was treated with oral succimer and operative removal of bullet fragments.
12
Deborah A. Cory‐Slechta, Bernard Weiss, Christopher Cox · Journal of Pharmacology and Experimental Therapeutics · 1987 · 164 citations
Identifying and managing adverse environmental health effects: 3. Lead exposure.
Margaret Sanborn, Alan Abelsohn, Monica Campbell et al. · PubMed · 2002 · 128 citations
Treatment Guidelines for Lead Exposure in Children
PEDIATRICS · 1995 · 90 citations
Pharmacy, Pharmacology, Toxicology +17