Halofuginone-an Inhibitor of Collagen Type I Synthesis-Prevents Postoperative Formation of Abdominal Adhesions

Abstract

Upregulation of collagen synthesis appears to have a critical role in the pathophysiology of postoperative adhesions. Halofuginone, an inhibitor of collagen type I synthesis, could be used as an important tool in understanding the role of collagen in adhesion formation, and it may become a novel and promising antifibrotic agent for preventing postoperative adhesion formation.