Retroviral gene transfer of an antisense construct against membrane type 1 matrix metalloproteinase reduces the invasiveness of rheumatoid arthritis synovial fibroblasts - Concepedia

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Retroviral gene transfer of an antisense construct against membrane type 1 matrix metalloproteinase reduces the invasiveness of rheumatoid arthritis synovial fibroblasts

58

Citations

20

References

2005

Year

Edita Rutkauskaite, Dagmar Volkmer, Yukio Shigeyama, Jörg Schedel, Géza Pap, Ulf Müller‐Ladner, Ingmar Meinecke, Dorothea Alexander, Renate E. Gay, Susanne Drynda,

Arthritis & Rheumatism

Abstract

The data demonstrate that an antisense RNA expression construct against MT1-MMP can be generated and expressed in RASFs for at least 60 days. Inhibition of MT1-MMP significantly reduces the cartilage degradation by RASFs.

References

	Year	Citations

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