Anti‐PP₁P^k and early abortion

Abstract

Anti‐PP 1 P k is found in the serum of individuals of phenotype p. Recurrent first trimester miscarriages have been reported in nearly 50 percent of mothers with the p phenotype. A comparative serologic study of three p phenotype mothers is reported. The proposita had three miscarriages while her two identical twin sisters had normal pregnancies. Following serum fractionation on DEAE‐cellulose, serial agglutination with P 1 and P 2 erythrocytes indicated a possible association between IgG anti‐P and the increased risk of abortion.