Spectroscopic Characterization and <i>in vitro</i> and <i>in vivo</i> Screening of Difluoro-Boron Complexes of NO and NS Donor Ligands

Abstract

Abstract Stereochemical and biochemical aspects of some difluoroboron complexes of the types BF2(NS) and BF2(NO) with ligands having (NS) and (NO) donor systems have been described. Based on IR, 1H NMR, 13C NMR, 19F NMR, and 11B NMR spectral studies, a tetracoordinated state of boron has been established. In order to assess their growth inhibiting potency the ligands and their fluoroboron complexes have been tested in vitro against a number of pathogenic fungi and bacteria at different concentrations and were found to possess remarkable fungicidal and bactericidal properties. The testicular morphology, testicular sperm density, sperm motility, density of cauda epididymal spermatozoa, and fertility in mating trails and biochemical parameters of reproductive organs with 2-acetylthiophene thiosemicarbazone, 2-acetylnaphthalene semicarbazone, and their fluoro complexes in vivo have also been examined and discussed.