Total Synthesis of the 13,13 Difluoro Analog of the 13 HODE

Abstract

The first total synthesis of the 13,13 difluoro analog of 13 HODE, via the novel fluorinated synthons (5) and (2), is reported. The key advantages of using a propargylic route for the introduction of the gem difluoro moiety are highlighted below. Keywords: fluorine, dast, 13 hode, lipids