Science · 1979 · 81 citations · 13 references
Veterinary MedicineOncologyToxicologyCancer ImmunologyCarcinogenesisNeoplasiaCarcinogenicity Of Dietary ExposuresLymphoid Organ ToxicityMalignant NeoplasmsReactive Nitrogen Species BiologyRodent OncologyRodent ToxicologyNitrate CarcinogenicityNitric Oxide BiologyNitrite CarcinogenicityNitrite ContaminationNitrosamine CarcinogenesisNitrosamine ExposureNitrosamine Formation
Rats were exposed to sodium nitrite in food or water at concentrations of 0, 250, 1000, and 2000 parts per million. Lymphoma was increased in all groups fed nitrite; the overall combined incidence was 5.4 percent in 573 control rats and 10.2 percent in 1383 treated rats. The mechanism of cancer induction did not appear to be through the formation of nitrosamines but through a more direct effect of nitrite on the lymphocyte.
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Nitrite and Nitrate Are Formed by Endogenous Synthesis in the Human Intestine
S R Tannenbaum, D. Fett, V. R. Young et al. · Science · 1978 · 288 citations