EXPERIMENTAL DIABETES INSIPIDUS

Abstract

<h3>INTRODUCTION AND HISTORY</h3> It has been known for a long time that tumors and other pathologic lesions in the region of the sella turcica are attended by far-reaching pathologic alterations in other parts of the body. For some time also it was a matter of dispute among clinicians as to whether the symptoms were due essentially to lesion of the pituitary gland or of the immediately adjacent base of the brain (Erdheim¹). Recently this controversy has arisen anew in the contradictory articles of Leschke²and Marañón.³ In 1907 Paulesco⁴opened the way to a solution of the question by developing a method of operative approach to the region of the sella. By this method, perfected by Cushing and developed by him and his associates, operative procedures on the pituitary gland became relatively easy. Cushing⁵was the first to note, after experimental lesions of the pituitary in dogs, the development of