Primary culture of chicken hepatocytes in serum-free medium (pH 7.8) secreted albumin and transferrin for a long period in free gas exchange with the atmosphere

Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver.

D. Montgomery Bissell, David M. Arenson, Jacquelyn J. Maher et al. · Journal of Clinical Investigation · 1987 · 550 citations · Full text

Tissue Engineering, Engineering, Cell Adhesion +24

Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

Avri Ben‐Ze'ev, Greg Robinson, Nancy L. R. Bucher et al. · Proceedings of the National Academy of Sciences · 1988 · 532 citations · Full text

Pathology, Cell Culture, Cell Proliferation +23

Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments

Norio Koide, Khosaku Sakaguchi, Yayoi Koide et al. · Experimental Cell Research · 1990 · 438 citations

Tissue Engineering, Multicellular Spheroids, Engineering +9

THE GROWTH AND MAINTENANCE OF TISSUE–CELL CULTURES IN FREE GAS EXCHANGE WITH THE ATMOSPHERE1

Albert Leibovitz · American Journal of Epidemiology · 1963 · 422 citations

Bioenergetics, Physiology, September 1963 +13

Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix.

R Enat, D M Jefferson, Nelson Ruiz‐Opazo et al. · Proceedings of the National Academy of Sciences · 1984 · 373 citations

Pathology, Cell Culture, Cell Proliferation +21