Radioimmunoassay of rheumatoid factor

Abstract

Abstract A radioimmunological method for assaying rheumatoid factor is proposed and analyzed. The method is based on the reaction between rheumatoid factor, either purified or present in serum, and purified labeled yg globulin. This assay permits a quantitative estimation of rheumatoid factor levels in rheumatoid‐positive serum and provides evidence that rheumatoid‐negative serum contains factors which can bind labeled yg globulin. Normal serum assayed by this method does not ordinarily contain such factors.