Diabetes Mellitus: Pathogenesis and Treatment Strategies

Concepts

MedicineEndocrinologyInternal MedicineDiabetologyMetabolic RegulationPathophysiologyDiabetes ControlDiabetes ManagementDiabetes MellitusDiabetes PharmacotherapyDiabetic NephropathyInsulin ResistanceAntidiabetic Drug TherapyDiabetes Mellitus ManagementDiabetes Mellitus MetabolismDiabetes Mellitus PathophysiologyDiabetes-related ComplicationsDiabetic ComplicationsTreatment Strategies

Abstract

This article introduces the disease state of diabetes mellitus and provides a background of the impact of the disease on the population, its biology and pathophysiology, and the current treatment strategies for treating diabetes.

References

Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study

Irene Stratton · BMJ · 2000 · 9K citations · Full text

Medicine, Chronic Disease Prevention, Internal Medicine +17

Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001

Ali H. Mokdad, Earl S. Ford, Barbara A. Bowman et al. · JAMA · 2003 · 5.9K citations

Public Health, Health Sciences, Disease Surveillance +7

Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial

Lennart Hansson, Alberto Zanchetti, S. George Carruthers et al. · The Lancet · 1998 · 5.8K citations

Medicine, Pharmacology, Pharmacotherapy +12

Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39

BMJ · 1998 · 1.4K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Effects of Calcium-Channel Blockade in Older Patients with Diabetes and Systolic Hypertension

Jaakko Tuomilehto, Daiva Rastenytė, W. H. Birkenhäger et al. · New England Journal of Medicine · 1999 · 946 citations · Full text

Pharmacy, Cardiology, Pharmacotherapy +15