Is log <i>P</i> a Convenient Criterion to Guide the Choice of Solvents for Biphasic Enzymatic Reactions?

Abstract

It depends on the choice. The conciliation of the high chemo- and enantioselectivity of the alcohol dehydrogenase(ADH)-catalyzed reduction of ketones and the poor water solubility of substrates can be achieved in aqueous–organic biphasic systems (see picture). But how should the organic phase be chosen? Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z51089_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.