Studies on polypeptides IV: Syntheses and activities of some angiotensin‐like peptides

Abstract

Abstract The following heptapeptides and octapeptides have been synthesized: (des‐Asp 1 )‐ L ‐Arg 2 (NO 2 )‐Ile 5 ‐angiotensin II, (des‐Asp 1 )‐ D ‐Arg 2 (NO 2 )‐Ile 5 ‐angiotensin II, D ‐Asp(NH 2 ) 1 ‐Ile 5 ‐angiotensin II, D ‐Asp(NH 2 ) 5 ‐ D ‐Arg 2 ‐Ile 5 ‐angiotensin II, Gly 1 ‐ D ‐Arg 2 ‐Ile 5 ‐angiotensin II, Asp 1 (NH 2 )‐Cit 2 ‐Ile 5− ‐angiotensin II*. Possible structure‐activity relationships are discussed.