Prospective Characterization of Norovirus Compared With Rotavirus Acute Diarrhea Episodes in Chilean Children

Abstract

Noroviruses are a significant cause of moderate to severe endemic ADE in Chilean children. Although significantly less severe than rotavirus as a group, most norovirus episodes were moderate to severe clinically. An effective norovirus vaccine would be of significant additional benefit to the current rotavirus vaccine in decreasing disease burden associated with ADE.