A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions

Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality

Dennis Lee, Scott A. Long, Jerry L. Adams et al. · Journal of Biological Chemistry · 2000 · 232 citations · Full text

Design, Synthesis, and Biological Evaluation of Isoquinoline-1,3,4-trione Derivatives as Potent Caspase-3 Inhibitors

Yihua Chen, Yahui Zhang, Hua-jie Zhang et al. · Journal of Medicinal Chemistry · 2006 · 126 citations · Full text

Bioorganic Chemistry, Cell Death, Isoquinoline-1,3,4-trione Derivatives +19

Concise and Versatile Multicomponent Synthesis of Multisubstituted Polyfunctional Dihydropyrroles

Qiuhua Zhu, Huanfeng Jiang, Jinghao Li et al. · Journal of Combinatorial Chemistry · 2009 · 120 citations

6-Substituted imidazo[1,2-a]pyridines: Synthesis and biological activity against colon cancer cell lines HT-29 and Caco-2

Nurit Dahan‐Farkas, Candice Langley, Amanda L. Rousseau et al. · European Journal of Medicinal Chemistry · 2011 · 109 citations

Biological Activity, Medicinal Chemistry, Biochemistry +7

<i>N</i>-Benzylisatin Sulfonamide Analogues as Potent Caspase-3 Inhibitors:  Synthesis, in Vitro Activity, and Molecular Modeling Studies

Wenhua Chu, Jun Zhang, Chenbo Zeng et al. · Journal of Medicinal Chemistry · 2005 · 104 citations · Full text

Chemoprevention Strategy, Immunology, Cell Death +22