Technometrics · 1962 · 119 citations · 6 references
PharmacyBiostatisticsExperimental DesignStatistical ModelingUncertainty QuantificationComputational ModelingModel BuildingModel CalibrationModel FittingModel FormulationParameter EstimationIterative DesignIterative Design ProcessIterative Hypothesis RefinementModel AssessmentModeling
Abstract A simple technique useful in iterative model-building is described. In this a statistical analysis is applied to the estimated parameters rather than to the observations directly. This mode of procedure pinpoints the source and nature of possible inadequacies and these, interacting with the experimenter's special knowledge of the problem, can suggest what modifications are necessary for improvement. The cycle may be repeated till an adequate model, which should of course be checked by additional critical experiments, is found.
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The 2 k-p Fractional Factorial Designs Part I
George E. P. Box, J. Stuart Hunter · Technometrics · 2000 · 416 citations
George E. P. Box · Annals of the New York Academy of Sciences · 1960 · 192 citations