Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

D. Craig Allred, Gary M. Clark, Richard Elledge, Suzanne A.W. Fuqua, Richard W. Brown, Gary C. Chamness, C. Kent Osborne, William McGuire

JNCI Journal of the National Cancer Institute · 1993 · 781 citations · 0 references

Abstract

This test, when combined with other prognostic factors, may enhance our ability to identify node-negative breast cancer patients at high risk for early disease recurrence and/or death, for whom the use of adjuvant chemotherapy is unequivocally justified.