SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

Timothy R. Peterson, Mathieu Laplante, Carson C. Thoreen et al. · Cell · 2009 · 1.2K citations · Full text

Hematological Malignancy, Mtor Inhibitor Frequently, Oncology +9

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

Peggy P. Hsu, Seong A. Kang, Jonathan Rameseder et al. · Science · 2011 · 1.1K citations · Full text

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

Yonghao Yu, Sang-Oh Yoon, George Poulogiannis et al. · Science · 2011 · 868 citations

Insulin Signaling, Signaling Pathway, Receptor Tyrosine Kinase +19

S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth

N. Valerio Dorrello, Angelo Peschiaroli, Daniele Guardavaccaro et al. · Science · 2006 · 703 citations

Molecular Biology, Cell Death, Cell Growth +18

SCF ^Fbxl3 Controls the Oscillation of the Circadian Clock by Directing the Degradation of Cryptochrome Proteins

Luca Busino, Florian Bassermann, Alessio Maiolica et al. · Science · 2007 · 494 citations

Molecular Regulation, Molecular Biology, Cryptochrome +17