Concepedia

<i>FoxO1</i> is required in endothelial but not myocardial cell lineages during cardiovascular development

Arunima Sengupta, Santanu Chakraborty, Jihye Paik, Katherine E. Yutzey, Heather J. Evans‐Anderson

Developmental Dynamics · 2012 · 37 citations · 27 references

DOIFull text

Open access

Abstract

The phenotype of Tie2Cre;FoxO1(fl/fl) mutant embryos demonstrates that FoxO1 is required specifically in endothelial cells to regulate formation of the heart and vasculature during development.

References

27

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

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Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo

Yaz Y. Kisanuki, Robert E. Hammer, Jun‐ichi Miyazaki et al. · Developmental Biology · 2001 · 1.2K citations

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FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis

Ji-Hye Paik, Ramya Kollipara, Gerald Chu et al. · Cell · 2007 · 1K citations · Full text

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Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

Luika Timmerman, Joaquím Grego‐Bessa, Ángel Raya et al. · Genes & Development · 2003 · 973 citations · Full text

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

Taisuke Hosaka, William Biggs, David Tieu et al. · Proceedings of the National Academy of Sciences · 2004 · 675 citations · Full text

, , +20