Concepedia

Congenital Liver Damage after Treatment of Mother with Valproic Acid and Phenytoin?

I. Felding, Anders Rane

Acta Paediatrica · 1984 · 20 citations · 11 references

DOI

Concepts

Abstract

A female neonate, whose mother had been treated throughout pregnancy with valproic acid and phenytoin, showed evident signs of liver damage, confirmed by laboratory investigations and biopsy.

References

11

Hepatotoxicity: The adverse effects of drugs and other chemicals on the liver

Willis C. Maddrey · Gastroenterology · 2000 · 648 citations · Full text

, , +14

Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.

Heinz Nau, D. Rating, S. Koch et al. · Journal of Pharmacology and Experimental Therapeutics · 1981 · 231 citations

, , +17

Acute Hepatic Failure Associated with the Use of Sodium Valproate

Frederick J. Suchy, William F. Balistreri, John J. Buchino et al. · New England Journal of Medicine · 1979 · 164 citations

, , +16

Teratogenicity of valproic acid: In vivo and in vitro investigations

John Y. Kao, Nigel A. Brown, Eugenia H. Goulding et al. · Teratogenesis Carcinogenesis and Mutagenesis · 1981 · 163 citations

, , +17

Tetracycline Toxicity in Pregnancy

Peggy J. Whalley, Reuben H. Adams, Burton Combes · JAMA · 1964 · 110 citations

, , +5