The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5K citations · Full text

Developmental Biology, Oncogenic Agent, Cellular Senescence +6

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

Adrian Merlo, James G. Herman, Li Mao et al. · Nature Medicine · 1995 · 2K citations

Tumor Biology, Transcriptional Regulation, Medicine +14

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

Stephen B. Baylln, James G. Herman, Jeremy R. Graff et al. · Advances in cancer research · 1997 · 1.9K citations

Chromatin, Epigenetic Change, Genetics +5

High sensitivity mapping of methylated cytosines

J.CIark Susan, Cheryl Paul, Marianne Frommer · Nucleic Acids Research · 1994 · 1.9K citations · Full text

COBRA: a sensitive and quantitative DNA methylation assay

Zhongguo Xiong, Peter W. Laird · Nucleic Acids Research · 1997 · 1.2K citations · Full text