Concepedia

Dipeptide Monoester Ganciclovir Prodrugs for Treating HSV-1-Induced Corneal Epithelial and Stromal Keratitis: <i>In Vitro</i> and <i>In Vivo</i> Evaluations

Soumyajit Majumdar, Yasser E. Nashed, Kunal Patel, Ritesh Jain, Motoki Itahashi, Donna M. Neumann, James M. Hill, Ashim K. Mitra

Journal of Ocular Pharmacology and Therapeutics · 2005 · 68 citations · 25 references

DOI

Abstract

Val-Val-GCV demonstrates excellent corneal permeability and chemical stability, high aqueous solubility, and substantial in vivo antiviral activity against the HSV-1.

References

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Effect of hydroxypropyl beta cyclodextrin complexation on aqueous solubility, stability, and corneal permeation of acyl ester prodrugs of ganciclovir

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