Synthetic Communications · 2008 · 12 citations · 7 references
Abstract 2-Carbonyl-1-indanolsCross-coupling ReactionGood YieldsEngineeringNatural SciencesDiversity-oriented SynthesisOrganic ChemistryOrganometallic CatalysisCatalysisChemistry2-Carbonyl- 1-IndanolsAsymmetric CatalysisOrthohalogenated Aryl AldehydeEfficient One-pot Synthesis
Abstract 2-Carbonyl-1-indanols were synthesized in moderate to good yields by the reaction of orthohalogenated aryl aldehyde with Morita–Baylis–Hillman adducts via a one-pot, palladium-catalyzed tandem Heck–aldol reaction. Various Morita–Baylis–Hillman adducts were examined to find the scope and limitations of this process.
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