Concepedia

Acetaminophen and analogs as cosubstrates and inhibitors of prostaglandin H synthase

Peter J. Harvison, Robert W. Egan, Paul H. Gale, Gary D. Christian, Brian S. Hill, Sidney D. Nelson

Chemico-Biological Interactions · 1988 · 48 citations · 32 references

DOI

Concepts

References

32

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

David C. Dahlin, Gerald T. Miwa, Albert Lu et al. · Proceedings of the National Academy of Sciences · 1984 · 1.1K citations

, , +16

Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)

R J Flower, John R. Vane · Nature · 1972 · 779 citations

, , +9

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

Robert W. Egan, James W. Paxton, F. A. Kuehl · Journal of Biological Chemistry · 1976 · 589 citations · Full text

, , +9

Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.

Martin E. Hemler, William E.M. Lands · Journal of Biological Chemistry · 1980 · 476 citations · Full text

, , +13

Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity.

Emanuele Albano, Mats Rundgren, Peter J. Harvison et al. · Molecular Pharmacology · 1985 · 313 citations

, , +17